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Mannitol Injection, Mannitol Intravenous, USP

Mannitol Intravenous is a medication used to reduce brain swelling and pressure caused by various conditions, such as head trauma or brain surgery. It works by drawing water out of the brain tissue, thereby decreasing swelling.

Mannitol is a 6-carbon sugar alcohol prepared commercially by the reduction of dextrose. Although virtually inert metabolically in humans, it occurs naturally in fruits and vegetables. Mannitol is an obligatory osmotic diuretic.

描述

Product Description: Mannitol
Product Alias: D-Mannitol, Mannite
Appearance: Mannitol is a white, crystalline powder or granules that are odorless and have a sweet taste.
Character: Mannitol is a sugar alcohol with a sweet taste and a cooling effect when consumed. It is non-toxic, highly soluble in water, and has a low hygroscopicity.
Category: Mannitol falls under the category of food additives and pharmaceutical excipients. It is widely used in the food and pharmaceutical industries.
Chemical Formula: C6H14O6
Molecular Formula: C6H14O6
Product Specifications:
  1. Purity: Mannitol is available in various purity levels, typically ranging from 98% to 99.5%. The higher the purity, the better the quality and performance.
  2. Particle Size: Mannitol is available in different particle sizes, including fine powder and granules, to suit different applications.
  3. Moisture Content: The moisture content of mannitol is an important specification, typically ranging from 0.5% to 1.5%. Lower moisture content ensures better stability and longer shelf life.
  4. pH Value: The pH value of mannitol solutions ranges from 5.0 to 7.5, making it suitable for a wide range of applications.
Pharmaceutical Industry Applications:
  1. Excipient in Tablet Formulations: Mannitol is widely used as an excipient in tablet formulations. It acts as a bulking agent, providing the necessary volume and compressibility for tablet production. It also enhances the disintegration and dissolution properties of tablets.
  2. Parenteral Formulations: Mannitol is used in parenteral formulations, such as intravenous solutions and injectable medications. It acts as an osmotic diuretic, helping to increase urine production and reduce intracranial pressure.
  3. Inhalation Therapy: Mannitol is utilized in inhalation therapy for the treatment of respiratory conditions, such as cystic fibrosis. It helps to hydrate and mobilize mucus, facilitating its clearance from the airways.
  4. Topical Formulations: Mannitol is used in topical formulations, including creams, gels, and ointments. It acts as a humectant, helping to retain moisture and improve the texture and stability of the product.
  5. Diagnostic Imaging: Mannitol is sometimes used as a contrast agent in diagnostic imaging procedures, such as computed tomography (CT) scans. It helps to enhance the visualization of certain structures or abnormalities.
Please note that the above information is a concise summary of Mannitol’s product description and its application in the pharmaceutical industry. For a more detailed manual, it is recommended to refer to the manufacturer’s documentation or consult relevant industry resources.

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